Neurobiological Correlates of Cognitions in Fear and Anxiety

Stefan G. Hofmann, Kristen K. Ellard, Greg J. Siegle — Thu, 07 Oct 2021 00:00:00 -0300

We review likely neurobiological substrates of cognitions related to fear and anxiety. Cognitive processes are linked to abnormal early activity reflecting hypervigilance in subcortical networks involving the amygdala, hippocampus, and insular cortex, and later recruitment of cortical regulatory resources, including activation of the anterior cingulate cortex and prefrontal cortex to implement avoidant response strategies. Based on this evidence, we present a cognitive-neurobiological information processing model of fear and anxiety, linking distinct brain structures to specific stages of information processing of perceived threat.

Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder

Erin B. McClure — Thu, 07 Oct 2021 00:00:00 -0300

Context: Considerable work implicates abnormal neural activation and disrupted attention to facial-threat cues in adult anxiety disorders. However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues.

Objective: To determine whether attention modulates amygdala and cortical responses to facial-threat cues differentially in adolescents with generalized anxiety disorder and in healthy adolescents.

Design: Case-control study.

Setting: Government clinical research institute.

Participants: Fifteen adolescents with generalized anxiety disorder and 20 controls.

Main outcome measures: Blood oxygenation level-dependent signal as measured via functional magnetic resonance imaging. During imaging, participants completed a face-emotion rating task that systematically manipulated attention.

Results: While attending to their own subjective fear, patients, but not controls, showed greater activation to fearful faces than to happy faces in a distributed network including the amygdala, ventral prefrontal cortex, and anterior cingulate cortex (P<.05, small-volume corrected, for all). Right amygdala findings appeared particularly strong. Functional connectivity analyses demonstrated positive correlations among the amygdala, ventral prefrontal cortex, and anterior cingulate cortex.

Conclusions: This is the first evidence in juveniles that generalized anxiety disorder-associated patterns of pathologic fear circuit activation are particularly evident during certain attention states. Specifically, fear circuit hyperactivation occurred in an attention state involving focus on subjectively experienced fear. These findings underscore the importance of attention and its interaction with emotion in shaping the function of the adolescent human fear circuit.

Fernanda Rufino

Neurobiological Correlates of Cognitions in Fear and Anxiety

Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder